Nishigandha Wad is a regular face on TV and films. Some of her Marathi films are Shejari Shejari (1990), Eka Peksha Ek, Bandhan (1991), Pratikar (1991), Bala Jo Jo Re (1993), Saasar Maaher (1994), and Ashi hi Dyaneshwari (2001). Some of the Hindi films in which she acted were Salim Langade Pe Mat Ro (1990), Karm Yodha (1992), Janmadata (1994), Daadagiri (1997), Deewangee (2002), Tumko Naa Bhool Payenge (2002), and Aap Mujhe Achche Lagne Lage (2002), Indian Babu (2003), Alibaba Aur 40 Chor (2004), Thoda Tum Badlo Thoda Hum (2004), Om Shanti - Fight For Peace (2008), Shaapit (2010), Rokkk (2010), Nidar - The Fearless (2011).
Nishigandha has also acted in many TV serials & shows like Kulvadhu (Marathi), Main Teri Parchhain Hoon (As Jaya’s mother Bharti), Sasural Simar Ka (As Prem's Mother), Waqt Batayega Kaun Apna Kaun Paraya (As Rudra's real-mother Sunanda, but acts as her nanny), etc.